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SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.1
USERS' SCORE
Good
Based on 1 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
7
Vitamin B12 may reduce breast cancer
Folic acid supplement use and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a case-control study.
Significant findings for BRCA carriers
We explored the impact of vitamin B12 supplement use on breast cancer risk among women with BRCA mutations. In a case-control study involving 129 breast cancer patients and 271 healthy controls, we evaluated the relationship between dietary supplements, including folic acid and vitamin B12, and breast cancer incidence.
Our findings revealed that women who took vitamin B12 supplements showed a significant decrease in breast cancer risk when compared to those who did not use these supplements. Specifically, moderate B12 intake was linked to a 52% reduction in risk.
Importantly, this association was most pronounced in women carrying the BRCA1 mutation. These results suggest that vitamin B12, in conjunction with folic acid supplements, may contribute to a lower risk of developing breast cancer among those genetically predisposed to the disease.
However, we recommend further studies to confirm these findings, as more extensive research with larger participant groups would help solidify our understanding of vitamin B12's benefits in this context.
Our findings revealed that women who took vitamin B12 supplements showed a significant decrease in breast cancer risk when compared to those who did not use these supplements. Specifically, moderate B12 intake was linked to a 52% reduction in risk.
Importantly, this association was most pronounced in women carrying the BRCA1 mutation. These results suggest that vitamin B12, in conjunction with folic acid supplements, may contribute to a lower risk of developing breast cancer among those genetically predisposed to the disease.
However, we recommend further studies to confirm these findings, as more extensive research with larger participant groups would help solidify our understanding of vitamin B12's benefits in this context.
Read More
8
Vitamin B12 linked to lower breast cancer
The Vitamins Involved in One-Carbon Metabolisms are Associated with Reduced Risk of Breast Cancer in Overall and Subtypes.
Focused on vitamin B12's role
We explored the potential link between vitamin B12 intake and breast cancer risk, as part of a broader investigation into the role of various micronutrients involved in one-carbon metabolism. In this study, we gathered dietary information from 151 breast cancer cases and 154 control participants using a detailed food frequency questionnaire.
After analyzing the data, it became clear that individuals with higher intakes of vitamin B12, along with other vitamins like B2, B6, and folate, showed significantly lower odds of developing breast cancer. Specifically, the odds were dramatically reduced across different subtypes of breast cancer, particularly for estrogen and progesterone receptor-positive cases.
However, it’s essential to note that while vitamin B12 seemed beneficial, it was evaluated alongside other vitamins, so pinpointing its specific effect alone can be challenging. Overall, our findings indicate that increasing dietary intake of vitamin B12 as part of a broader nutritional approach may be associated with a lower risk of breast cancer, although its effect should be considered within the context of other nutrients.
After analyzing the data, it became clear that individuals with higher intakes of vitamin B12, along with other vitamins like B2, B6, and folate, showed significantly lower odds of developing breast cancer. Specifically, the odds were dramatically reduced across different subtypes of breast cancer, particularly for estrogen and progesterone receptor-positive cases.
However, it’s essential to note that while vitamin B12 seemed beneficial, it was evaluated alongside other vitamins, so pinpointing its specific effect alone can be challenging. Overall, our findings indicate that increasing dietary intake of vitamin B12 as part of a broader nutritional approach may be associated with a lower risk of breast cancer, although its effect should be considered within the context of other nutrients.
Read More
8
Vitamin B12 enhances cancer treatment
Cobalamin (Vitamin B12) in Anticancer Photodynamic Therapy with Zn(II) Phthalocyanines.
Moderate relevance for vitamin B12
We explored how vitamin B12, specifically hydroxycobalamin (Cbl), affects the effectiveness of zinc(II) phthalocyanines in treating breast cancer. In our study, we focused on two breast cancer cell lines, MDA-MB-231 and MCF-7, and compared these to normal cell lines. This approach allowed us to evaluate the potential benefits of adding vitamin B12 to the treatment protocol.
The results were quite revealing. We observed that both zinc complexes showed strong photocytotoxicity, especially 3ZnPc, which was effective even at low concentrations. When we introduced Cbl into the mix, the phototoxic effect of 3ZnPc increased significantly, needing even lesser concentrations to achieve remarkable results. Moreover, we noted a reduction in dark toxicity, which means that the treatment might be safer when Cbl is involved.
Perhaps most importantly, the addition of Cbl improved the selectivity of 3ZnPc towards cancer cells compared to normal cells, enhancing its therapeutic potential. Overall, our findings suggest that incorporating vitamin B12 could boost the effectiveness of certain cancer treatments while minimizing harmful side effects.
The results were quite revealing. We observed that both zinc complexes showed strong photocytotoxicity, especially 3ZnPc, which was effective even at low concentrations. When we introduced Cbl into the mix, the phototoxic effect of 3ZnPc increased significantly, needing even lesser concentrations to achieve remarkable results. Moreover, we noted a reduction in dark toxicity, which means that the treatment might be safer when Cbl is involved.
Perhaps most importantly, the addition of Cbl improved the selectivity of 3ZnPc towards cancer cells compared to normal cells, enhancing its therapeutic potential. Overall, our findings suggest that incorporating vitamin B12 could boost the effectiveness of certain cancer treatments while minimizing harmful side effects.
Read More
Most Useful Reviews
2.5
Cancer recurrence risk
I was using Methyl B-12 but had to stop after a CBC revealed my vitamin B-12 level was extraordinarily high. Having previously had breast cancer, I learnt that taking B-12 may increase the likelihood of cancer returning, according to my nutritionist and various articles I discovered. While it might be beneficial for some, it’s certainly not suitable for me.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.1
8
Vitamin B12 enhances cancer treatment
Cobalamin (Vitamin B12) in Anticancer Photodynamic Therapy with Zn(II) Phthalocyanines.
Moderate relevance for vitamin B12
We explored how vitamin B12, specifically hydroxycobalamin (Cbl), affects the effectiveness of zinc(II) phthalocyanines in treating breast cancer. In our study, we focused on two breast cancer cell lines, MDA-MB-231 and MCF-7, and compared these to normal cell lines. This approach allowed us to evaluate the potential benefits of adding vitamin B12 to the treatment protocol.
The results were quite revealing. We observed that both zinc complexes showed strong photocytotoxicity, especially 3ZnPc, which was effective even at low concentrations. When we introduced Cbl into the mix, the phototoxic effect of 3ZnPc increased significantly, needing even lesser concentrations to achieve remarkable results. Moreover, we noted a reduction in dark toxicity, which means that the treatment might be safer when Cbl is involved.
Perhaps most importantly, the addition of Cbl improved the selectivity of 3ZnPc towards cancer cells compared to normal cells, enhancing its therapeutic potential. Overall, our findings suggest that incorporating vitamin B12 could boost the effectiveness of certain cancer treatments while minimizing harmful side effects.
The results were quite revealing. We observed that both zinc complexes showed strong photocytotoxicity, especially 3ZnPc, which was effective even at low concentrations. When we introduced Cbl into the mix, the phototoxic effect of 3ZnPc increased significantly, needing even lesser concentrations to achieve remarkable results. Moreover, we noted a reduction in dark toxicity, which means that the treatment might be safer when Cbl is involved.
Perhaps most importantly, the addition of Cbl improved the selectivity of 3ZnPc towards cancer cells compared to normal cells, enhancing its therapeutic potential. Overall, our findings suggest that incorporating vitamin B12 could boost the effectiveness of certain cancer treatments while minimizing harmful side effects.
Read More
8
Vitamin B12 linked to lower breast cancer
The Vitamins Involved in One-Carbon Metabolisms are Associated with Reduced Risk of Breast Cancer in Overall and Subtypes.
Focused on vitamin B12's role
We explored the potential link between vitamin B12 intake and breast cancer risk, as part of a broader investigation into the role of various micronutrients involved in one-carbon metabolism. In this study, we gathered dietary information from 151 breast cancer cases and 154 control participants using a detailed food frequency questionnaire.
After analyzing the data, it became clear that individuals with higher intakes of vitamin B12, along with other vitamins like B2, B6, and folate, showed significantly lower odds of developing breast cancer. Specifically, the odds were dramatically reduced across different subtypes of breast cancer, particularly for estrogen and progesterone receptor-positive cases.
However, it’s essential to note that while vitamin B12 seemed beneficial, it was evaluated alongside other vitamins, so pinpointing its specific effect alone can be challenging. Overall, our findings indicate that increasing dietary intake of vitamin B12 as part of a broader nutritional approach may be associated with a lower risk of breast cancer, although its effect should be considered within the context of other nutrients.
After analyzing the data, it became clear that individuals with higher intakes of vitamin B12, along with other vitamins like B2, B6, and folate, showed significantly lower odds of developing breast cancer. Specifically, the odds were dramatically reduced across different subtypes of breast cancer, particularly for estrogen and progesterone receptor-positive cases.
However, it’s essential to note that while vitamin B12 seemed beneficial, it was evaluated alongside other vitamins, so pinpointing its specific effect alone can be challenging. Overall, our findings indicate that increasing dietary intake of vitamin B12 as part of a broader nutritional approach may be associated with a lower risk of breast cancer, although its effect should be considered within the context of other nutrients.
Read More
7
Methyl-donors for breast cancer
Methyl-Donors Can Induce Apoptosis and Attenuate Both the Akt and the Erk1/2 Mediated Proliferation Pathways in Breast and Lung Cancer Cell Lines.
Complex effects of vitamin B12
We examined how dietary methyl-donors, particularly a mixture that includes vitamin B12, might influence breast cancer cell lines. Our focus was on well-known breast cancer cell lines, MCF7 and T47D, to see if these compounds could help in reducing cancer growth and improving responses to treatment.
The findings were noteworthy; the methyl-donor treatment significantly decreased cell proliferation in both cell lines. It appeared that this effect was linked to changes in critical pathways that promote growth, specifically the MAPK/ERK and AKT signaling pathways. Furthermore, we noticed an increase in proteins that encourage apoptosis—like Bak and Bax—while levels of anti-apoptotic proteins such as Mcl-1 and Bcl-2 went down.
One remarkable aspect was the downregulation of specific protein modifications related to p53, a crucial molecule in regulating cell death and survival. This suggests that methyl-donors, including vitamin B12, might help maintain p53's function, which is essential during cancer therapy. However, it's important to note that the unique impact of vitamin B12 alone was difficult to evaluate, as its effects were studied alongside other methyl-donors.
Overall, while our study offers insights into the potential benefits of methyl-donors in breast cancer treatment, further research is needed to confirm these findings in clinical settings and assess their safety. We believe exploring dietary supports like vitamin B12 could be a valuable avenue for enhancing cancer care.
The findings were noteworthy; the methyl-donor treatment significantly decreased cell proliferation in both cell lines. It appeared that this effect was linked to changes in critical pathways that promote growth, specifically the MAPK/ERK and AKT signaling pathways. Furthermore, we noticed an increase in proteins that encourage apoptosis—like Bak and Bax—while levels of anti-apoptotic proteins such as Mcl-1 and Bcl-2 went down.
One remarkable aspect was the downregulation of specific protein modifications related to p53, a crucial molecule in regulating cell death and survival. This suggests that methyl-donors, including vitamin B12, might help maintain p53's function, which is essential during cancer therapy. However, it's important to note that the unique impact of vitamin B12 alone was difficult to evaluate, as its effects were studied alongside other methyl-donors.
Overall, while our study offers insights into the potential benefits of methyl-donors in breast cancer treatment, further research is needed to confirm these findings in clinical settings and assess their safety. We believe exploring dietary supports like vitamin B12 could be a valuable avenue for enhancing cancer care.
Read More
7
Vitamin B12 may reduce breast cancer
Folic acid supplement use and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a case-control study.
Significant findings for BRCA carriers
We explored the impact of vitamin B12 supplement use on breast cancer risk among women with BRCA mutations. In a case-control study involving 129 breast cancer patients and 271 healthy controls, we evaluated the relationship between dietary supplements, including folic acid and vitamin B12, and breast cancer incidence.
Our findings revealed that women who took vitamin B12 supplements showed a significant decrease in breast cancer risk when compared to those who did not use these supplements. Specifically, moderate B12 intake was linked to a 52% reduction in risk.
Importantly, this association was most pronounced in women carrying the BRCA1 mutation. These results suggest that vitamin B12, in conjunction with folic acid supplements, may contribute to a lower risk of developing breast cancer among those genetically predisposed to the disease.
However, we recommend further studies to confirm these findings, as more extensive research with larger participant groups would help solidify our understanding of vitamin B12's benefits in this context.
Our findings revealed that women who took vitamin B12 supplements showed a significant decrease in breast cancer risk when compared to those who did not use these supplements. Specifically, moderate B12 intake was linked to a 52% reduction in risk.
Importantly, this association was most pronounced in women carrying the BRCA1 mutation. These results suggest that vitamin B12, in conjunction with folic acid supplements, may contribute to a lower risk of developing breast cancer among those genetically predisposed to the disease.
However, we recommend further studies to confirm these findings, as more extensive research with larger participant groups would help solidify our understanding of vitamin B12's benefits in this context.
Read More
5
Vitamin B12 linked to poor outcomes
Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221).
Study highlights caution on supplementation
We conducted a comprehensive study to understand how vitamin B12 influences breast cancer outcomes when patients are undergoing chemotherapy. Our research involved women with breast cancer who participated in a trial where they received various treatments including cyclophosphamide, doxorubicin, and paclitaxel.
During this trial, we gathered information about the women’s use of dietary supplements, specifically focusing on vitamin B12. What we found was quite striking: the use of vitamin B12 both before and during chemotherapy was linked to poorer disease-free and overall survival rates. Our analysis showed that patients who took vitamin B12 had an adjusted hazard ratio indicating a significantly increased risk, suggesting that this supplement may not offer the benefit some might expect during cancer treatment.
This information highlights the importance of caution when considering dietary supplements during chemotherapy. Our findings align with recommendations urging patients to avoid supplements, other than a multivitamin, while undergoing such critical treatment. Ultimately, this study calls for careful consultation with healthcare providers about any supplement intake during breast cancer therapy.
During this trial, we gathered information about the women’s use of dietary supplements, specifically focusing on vitamin B12. What we found was quite striking: the use of vitamin B12 both before and during chemotherapy was linked to poorer disease-free and overall survival rates. Our analysis showed that patients who took vitamin B12 had an adjusted hazard ratio indicating a significantly increased risk, suggesting that this supplement may not offer the benefit some might expect during cancer treatment.
This information highlights the importance of caution when considering dietary supplements during chemotherapy. Our findings align with recommendations urging patients to avoid supplements, other than a multivitamin, while undergoing such critical treatment. Ultimately, this study calls for careful consultation with healthcare providers about any supplement intake during breast cancer therapy.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Reviews
8
2.5
Cancer recurrence risk
I was using Methyl B-12 but had to stop after a CBC revealed my vitamin B-12 level was extraordinarily high. Having previously had breast cancer, I learnt that taking B-12 may increase the likelihood of cancer returning, according to my nutritionist and various articles I discovered. While it might be beneficial for some, it’s certainly not suitable for me.
Read More
